Alector Initiates First-in-Human Dosing in Phase 1 Study of AL101 for the Treatment of Neurodegenerative Diseases
- AL101 is the company’s second product candidate designed to increase the level of progranulin in the human brain.
- Progranulin has been identified as a key regulator of microglial function in the brain with strong genetic links to multiple neurodegenerative disorders.
AL101 is Alector’s second product candidate targeting the progranulin pathway to enter the clinic in the last two years.
“Progranulin is a regulator of immune activity in the brain. Human genetics have shown that even moderately reduced progranulin expression may lead to an increased risk of developing neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. We strongly believe that increasing progranulin in the brain of patients suffering from these diseases may counteract disease pathology,” said
“This study will pave the way for exploring multiple indications for progranulin therapy as well as delivery formulations of this novel investigational medicine. The results will inform our decisions on future development of AL101 for neurodegeneration,” said
The Phase 1 study of AL101 is a randomized, double-blind, placebo-controlled trial expected to enroll up to 42 healthy volunteers at a clinical study site in
AL101 is Alector’s wholly-owned human monoclonal antibody and second product designed to increase progranulin, a regulator of immune activity in the brain with genetic links to multiple neurodegenerative disorders. Mutations that moderately reduce the expression levels of progranulin have been shown to increase the risk of developing Alzheimer’s disease and Parkinson’s disease, and increased progranulin levels have been demonstrated to be protective for these diseases in animal models.
AL101 has the potential to be developed for the treatment of Alzheimer’s disease and Parkinson’s disease. AL101 received orphan drug designation from the
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Source: Alector, Inc.