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Important Notice Regarding the Availability of Proxy Materials for the Stockholder Meeting of ALECTOR, INC. To Be Held On: June 17, 2021 Meeting live via the Internet—please visit password: alector2021 (cap sensitive) COMPANY NUMBER ACCOUNT NUMBER CONTROL NUMBER encourage you to access and review all of the important information contained in the proxy materials before voting. If you want to receive a paper or e-mail copy of the proxy materials you must request one. There is no charge to you for requesting a copy. To facilitate timely delivery please make the request as instructed below before May 31, 2021. Please visit, where the following materials are available for view: Notice of Annual Meeting of Stockholders Proxy Statement Proxy Card Annual Report on Form 10-K TELEPHONE: 888-Proxy-NA (888-776-9962) or 718-921-8562 (for international callers) E-MAIL: WEBSITE: ONLINE: To access your online proxy card, please visit and follow the on-screen instructions or scan the QR code with your smartphone. You may enter your voting instructions at up until 11:59 PM Eastern Time the day before the meeting date. DURING THE MEETING: The company will be hosting the meeting live via the Internet this year. To attend the meeting via the Internet please visit password: alector2021 (cap sensitive) and be sure to have available the control number. MAIL: You may request a proxy card by following the instructions above. TO OBTAIN PROXY MATERIALS: TO VOTE: 1. ELECTION OF DIRECTORS: Tillman Richard Gerngross, Scheller, Ph.D. D. Louis J. Lavigne, Jr. Ph. Please note that you cannot use this notice to vote by mail. 2. Ratification of the appointment of Ernst & Young, LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2021. 3. Advisory vote on executive compensation. 4. Advisory vote on the frequency of advisory votes on executive compensation. THE BOARD OF DIRECTORS RECOMMENDS THAT YOU VOTE “FOR” THE NOMINEES LISTED IN PROPOSAL 1, “FOR” PROPOSALS 2 AND 3, AND FOR THE FREQUENCY OF EVERY “ONE YEAR” FOR PROPOSAL 4.